Cytokine response in SARS-CoV-2 infection in the elderly

S Sherwani, MWA Khan - Journal of Inflammation Research, 2020 - Taylor & Francis
The last few months of 2019 witnessed the emergence, rise and rapid spread of a novel
coronavirus known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …

[HTML][HTML] Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people

J Vitallé, A Pérez-Gómez, FJ Ostos, C Gasca-Capote… - JCI insight, 2022 - ncbi.nlm.nih.gov
The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly
people are mostly unknown. We studied individuals older than 60 and younger than 60 …

[HTML][HTML] Influence of aging on deterioration of patients with COVID-19

L Pang, Y Liu, M Shen, J Ye, R Chen, Z Lan… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Aging is an important factor affecting the deterioration of patients with coronavirus disease
2019 (COVID-19). The aging and degeneration of various tissues and organs in the elderly …

[HTML][HTML] Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

[HTML][HTML] The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …

[HTML][HTML] Age-related changes in plasma biomarkers and their association with mortality in COVID-19

EHA Michels, B Appelman… - European …, 2023 - Eur Respiratory Soc
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly
in older patients. Several immunomodulating therapies seem less beneficial in these …

Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes

J Sabbatinelli, G Matacchione, A Giuliani… - Mechanisms of Ageing …, 2022 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 infection has been of unprecedented
clinical and socio-economic worldwide relevance. The case fatality rate for COVID-19 grows …

Role of aging and the immune response to respiratory viral infections: potential implications for COVID-19

J Chen, WJ Kelley, DR Goldstein - The Journal of Immunology, 2020 - journals.aai.org
Aging impairs immunity to promote diseases, especially respiratory viral infections. The
current COVID-19 pandemic, resulting from SARS-CoV-2, induces acute pneumonia, a …

[HTML][HTML] Severe COVID-19 and aging: are monocytes the key?

BD Pence - Geroscience, 2020 - Springer
The ongoing pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
causes a disproportionate number of severe cases and deaths in older adults. Severe SARS …

Immunosenescence and inflamm-ageing in COVID-19

MR Zinatizadeh, PK Zarandi, M Ghiasi… - Ageing Research …, 2023 - Elsevier
The destructive effects of coronavirus disease 2019 (COVID-19) on the elderly and people
with cardiovascular disease have been proven. New findings shed light on the role of aging …