Hepatitis C virus (HCV) enters cells via interactions with several host factors, a key one
being that between the viral E2 envelope glycoprotein and the CD81 receptor. We …

The envelope glycoprotein E2 of hepatitis C virus (HCV) is the target of neutralizing
antibodies and is presently being evaluated as an HCV vaccine candidate. HCV binds to …

Hepatitis C virus (HCV) glycoprotein E2 binds to human cells by interacting with the CD81
molecule, which has been proposed to be the viral receptor. A correlation between binding …

ABSTRACT A truncated soluble form of the hepatitis C virus E2 glycoprotein, E2661, binds
specifically to the surface of cells expressing human CD81 (hCD81) but not other members …

Human CD81 has been previously identified as the putative receptor for the hepatitis C virus
envelope glycoprotein E2. The large extracellular loop (LEL) of human CD81 differs in four …

Hepatitis C virus (HCV) cell entry involves interaction between the viral envelope
glycoprotein E2 and the cell surface receptor CD81. Knowledge of conserved E2 …

The hepatitis C virus (HCV) glycoproteins E1 and E2 form a heterodimer that mediates
CD81 receptor binding and viral entry. In this study, we used site-directed mutagenesis to …

Hepatitis C virus (HCV) infection is a causal agent of chronic liver disease, cirrhosis and
hepatocellular carcinoma in humans, and afflicts more than 70 million people worldwide …

The hepatitis C virus glycoprotein E2 receptor-binding domain is encompassed by amino
acids 384 to 661 (E2661) and contains two hypervariable sequences, HVR1 and HVR2. E2 …

Hepatitis C virus (HCV) infects cells by the direct uptake of cell-free virus following virus
engagement with specific cell receptors such as CD81. Recent data have shown that HCV is …