[HTML][HTML] Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and …

Z Chen, Y Dong, Q Yan, Q Li, C Yu, Y Lai, J Tan… - Frontiers in …, 2023 - frontiersin.org
The drug pair consisting of Sophora flavescens Aiton (Sophorae flavescentis radix, Kushen)
and Coptis chinensis Franch.(Coptidis rhizoma, Huanglian), as described in Prescriptions …

Screening on alkaloid of Sophora alopecuraides against adenocarcinoma of colon cell line SW620 in vitro

L Liang, XY Wang, XH Zhang, WC Zhao… - Zhong yao cai …, 2008 - europepmc.org
Objective To test 5 kinds of alkaloid of Sophora alopecuraides L., the effects of TBSA, MT,
OMT, SC, SRI against adenocarcinoma of colon cell line SW620. Methods SW620 cell line …

Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway

LY Han, H Yu, S Wang, YR Bao, TJ Li, Y Zheng… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Colorectal cancer (CRC) belongs to the category of
intestinal wind, anal ulcer, abdominal mass and other diseases in traditional Chinese …

[HTML][HTML] Exploring the mechanism of action of Sanzi formula in intervening colorectal adenoma by targeting intestinal flora and intestinal metabolism

J Shang, H Guo, J Li, Z Li, Z Yan, L Wei, Y Hua… - Frontiers in …, 2022 - frontiersin.org
Background Sanzi formula (SZF) is a kind of Chinese herbal compound that has a certain
effect on the prevention and treatment of colorectal adenoma (CRA), which can prevent and …

[HTML][HTML] Network Pharmacology and Transcriptomic Sequencing Analyses Reveal the Molecular Mechanism of Sanguisorba officinalis Against Colorectal Cancer

W Zhang, S Sang, C Peng, GQ Li, L Ou, Z Feng… - Frontiers in …, 2022 - frontiersin.org
Background Colorectal cancer (CRC) is the most common malignant cancer worldwide.
Sanguisorba officinalis has been shown to have anti-inflammatory, anti-bacterial …

[HTML][HTML] Design and synthesis of molecular hybrids of Sophora alkaloids and cinnamic acids as potential antitumor agents

H Shang, L Li, L Ma, Y Tian, H Jia, T Zhang, M Yu… - Molecules, 2020 - mdpi.com
Twenty-five sophora alkaloids-cinnamic acid hybrids (including matrine-cinnamic acid
hybrids, sophoridine-cinnamic acid hybrids, and sophocarpine-cinnamic acid hybrids) were …

Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer

MH Chen, YY Gu, AL Zhang, DM Sze, SL Mo… - Pharmacological …, 2021 - Elsevier
Abstract The plant Sophora flavescens Ait. has been used in the clinical management of
colorectal cancer (CRC). Its constituent compounds, notably the alkaloids matrine …

[HTML][HTML] Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting …

H Yu, H Xu, X Yang, Z Zhang, J Hu, J Lu, J Fu… - Journal of …, 2023 - Elsevier
Specnuezhenide (SNZ) is among the main components of Fructus Ligustri Lucidi, which has
anti-inflammation, anti-oxidation, and anti-tumor effect. The low bioavailability makes it …

A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway

X Zhang, Z Liu, S Chen, H Li, L Dong, X Fu - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance Bupleurum chinense DC has a history of using herb in
China for more than 2000 years, which can be traced back to the Classic of Shennong …

[HTML][HTML] Uncovering the effects and molecular mechanism of Astragalus membranaceus (Fisch.) Bunge and its bioactive ingredients formononetin and calycosin …

Y Hu, W Zhai, D Tan, H Chen, G Zhang… - Frontiers in …, 2023 - frontiersin.org
Colon cancer is a highly malignant cancer with poor prognosis. Astragalus membranaceus
(Fisch.) Bunge (Huang Qi in Chinese, HQ), a well-known Chinese herbal medicine and a …