Innate immunity and adipocyte function: ligand‐specific activation of multiple Toll‐like receptors modulates cytokine, adipokine, and chemokine secretion in …

A Kopp, C Buechler, M Neumeier, J Weigert… - …, 2009 - Wiley Online Library
The aim of this study was to analyze Toll‐like receptor (TLR) expression in preadipocytes
and mature adipocytes and to investigate whether TLR ligands influence the release of …

Diet-induced obesity reduces the production of influenza vaccine-induced antibodies via impaired macrophage function.

WJ Cho, DK Lee, SY Lee, SH Sohn, HL Park… - Acta virologica, 2016 - europepmc.org
Obesity is a metabolic disease characterized by low-level chronic inflammation. Obese
individuals are susceptible to infection by viruses, and vaccination against these pathogens …

Feeding our immune system: impact on metabolism

I Wolowczuk, C Verwaerde, O Viltart… - Journal of …, 2008 - Wiley Online Library
Endogenous intestinal microflora and environmental factors, such as diet, play a central role
in immune homeostasis and reactivity. In addition, microflora and diet both influence body …

Immunity as a link between obesity and insulin resistance

NS Kalupahana, N Moustaid-Moussa… - Molecular aspects of …, 2012 - Elsevier
Obesity is a major public health problem in the United States and worldwide. Further, obesity
is causally linked to the pathogenesis of insulin resistance, metabolic syndrome and type-2 …

The effects of type 2 diabetes mellitus on organ metabolism and the immune system

G Daryabor, MR Atashzar, D Kabelitz, S Meri… - Frontiers in …, 2020 - frontiersin.org
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

Innate immune activation in obesity

CN Lumeng - Molecular aspects of medicine, 2013 - Elsevier
The innate immune system is a prewired set of cellular and humoral components that has
developed to sense perturbations in normal physiology and trigger responses to restore the …

From influenza virus to novel corona virus (SARS-CoV-2)–The contribution of obesity

I Bhattacharya, C Ghayor… - Frontiers in …, 2020 - frontiersin.org
From the beginning of 2020, the governments and the health systems around the world are
tackling infections and fatalities caused by the novel severe acute respiratory syndrome …

Pediatric obesity and the immune system

GR Umano, C Pistone, E Tondina, A Moiraghi… - Frontiers in …, 2019 - frontiersin.org
Obesity has reached pandemic proportion and represents a major risk for several
comorbidities. In addition to metabolic and cardiovascular obesity-related diseases, recent …

Diverse effects of obesity on antitumor immunity and immunotherapy

L Dyck, L Lynch - Trends in Molecular Medicine, 2023 - cell.com
Currently, obesity is one of the biggest health burdens facing society because it causes
several comorbidities, such as type 2 diabetes, atherosclerosis, and heart disease. Obesity …

COVID‐19, obesity, and immune response 2 years after the pandemic: A timeline of scientific advances

M Belchior‐Bezerra, RS Lima, NI Medeiros… - Obesity …, 2022 - Wiley Online Library
In the 2 years since the COVID‐19 pandemic was officially declared, science has made
considerable strides in understanding the disease's pathophysiology, pharmacological …