The CAM model—Q&A with experts

D Fischer, G Fluegen, P Garcia… - Cancers, 2022 - mdpi.com
Simple Summary The chorioallantoic membrane (CAM) model is an alternative in vivo test
system for the study of hallmarks of cancer such as angiogenesis, tumor growth, immune …

[HTML][HTML] Applications of the chick chorioallantoic membrane as an alternative model for cancer studies

PY Chu, APF Koh, J Antony, RYJ Huang - Cells Tissues Organs, 2022 - karger.com
A variety of in vivo experimental models have been established for the studies of human
cancer using both cancer cell lines and patient-derived xenografts (PDXs). In order to meet …

The in ovo chick chorioallantoic membrane (CAM) assay as an efficient xenograft model of hepatocellular carcinoma

M Li, RR Pathak, E Lopez-Rivera, SL Friedman… - JoVE (Journal of …, 2015 - jove.com
The chick chorioallantoic membrane (CAM) begins to develop by day 7 after fertilization and
matures by day 12. The CAM is naturally immunodeficient and highly vascularized, making it …

The chick embryo chorioallantoic membrane as a model for tumor biology

D Ribatti - Experimental cell research, 2014 - Elsevier
Among the in vivo models, the chick embryo chorioallantoic membrane (CAM) has been
used to implant several tumor types as well as malignant cell lines to study their growth rate …

The chick embryo chorioallantoic membrane model: a research approach for ex vivo and in vivo experiments

AI Fraguas-Sánchez, C Martín-Sabroso… - Current medicinal …, 2022 - ingentaconnect.com
Background: The chick chorioallantoic membrane (CAM) model has attracted a great deal of
interest in pharmaceutical and biological research as an alternative or complimentary in vivo …

The CAM assay as an alternative in vivo model for drug testing

R Schneider-Stock, D Ribatti - Organotypic Models in Drug Development, 2021 - Springer
In the last decade, the chicken chorioallantoic membrane (CAM) assay has been re-
discovered in cancer research to study the molecular mechanisms of anti-cancer drug …

The CAM assay in the study of the metastatic process

D Ribatti - Experimental cell research, 2021 - Elsevier
Among the in vivo experimental models, the chick embryo chorioallantoic membrane (CAM)
has been routinely used to implant several malignant cell lines or tumor tissues to study their …

Chick embryo chorioallantoic membrane model systems to study and visualize human tumor cell metastasis

EI Deryugina, JP Quigley - Histochemistry and cell biology, 2008 - Springer
Since their introduction almost a century ago, chick embryo model systems involving the
technique of chorioallantoic grafting have proved invaluable in the in vivo studies of tumor …

[HTML][HTML] The chick chorioallantoic membrane (CAM) as a versatile patient-derived xenograft (PDX) platform for precision medicine and preclinical research

LC DeBord, RR Pathak, M Villaneuva… - American Journal of …, 2018 - ncbi.nlm.nih.gov
Patient-derived xenografts (PDX) are an increasingly valuable tool in oncology, providing
biologically faithful models of many different cancer types, and potential platforms for the …

[HTML][HTML] The chick embryo chorioallantoic membrane (CAM). A multifaceted experimental model

D Ribatti - Mechanisms of development, 2016 - Elsevier
During avian development the mesodermal layers of the allantois and chorion fuse to form
the chorioallantoic membrane (CAM). This structure rapidly expands generating a rich …