The cross talk between immune and non-immune cells in the tumor microenvironment leads
to immunosuppression, which promotes tumor growth and survival. Immunotherapy is an …

Tissue engineering aims to structurally and functionally regenerate damaged tissues, which
requires the formation of new blood vessels that supply oxygen and nutrients by the process …

Immune checkpoint inhibitors (ICIs) have drastically changed the clinical care of cancer.
Although cancer immunotherapy has shown promise in various types of malignancies, thus …

Simple Summary Cell-to-cell communication between the immune system and tumors is of
the utmost importance; it influences the development of tumors, their growth, and how they …

The landscape in immuno-oncology (IO) has undergone profound changes since its early
beginnings up through the rapid advances happening today. The current drug development …

Simple Summary Circulating cancer cells—and in particular their very rare subpopulation,
circulating cancer stem cells (cCSCs)—are responsible for recurrence and metastasis. In …

Despite the continuous improvement of various therapeutic techniques, the overall
prognosis of tumors has been significantly improved, but malignant tumors in the middle and …

Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting
effects, and demonstrated improved overall survival and tolerance, when compared to …

EpCAM, known as an epithelial cell adhesion molecule, plays an essential role in cell
adhesion, migration, metastasis and cell signalling. Rather than acting as an apoptosis …

Supported by the Office of International Affairs, National Cancer Institute (NCI), the" US-
Japan Workshop on Immunological Biomarkers in Oncology" was held in March 2009. The …