Christopher L. Murriel et al.,“Influence of protein transduction domains on intracellular
delivery of macromolecules'. Expert Opin ion on Drug Delivery, Informational Healthcare …

0003. The present invention relates to gene therapy, espe cially to adenovirus vector-based
gene therapy. In particular, adenovirus vectors complexed with bifunctional molecules for …

BACKGROUND OF INVENTION [0002] Targeted delivery of therapeutic and diagnostic
agents has largely relied on associating the agent with a targeting molecule that binds to an …

BACKGROUND [0001] In the biotechnology industry, there is a great inter est in being able
to deliver macromolecules such as DNA, RNA, and proteins to the cytoplasm of cells in order …

Compositions and methods are described for non-viral nucleic acid delivery. A targeting
peptide capable of mediat ing targeting to a cell or Subcellular compartment is deriva tized …

0002 This invention relates to therapeutic and imaging agents which are comprised of a
targeting entity, a linking carrier, and optionally, a therapeutic or treatment entity. The …

Targeting liposomes that include a non-peptidic integrin receptor antagonist and a nucleic
acid are provided by the present invention. These targeting liposomes are useful for …

The present invention relates to the delivery of biologically active molecules, such as
peptides, nucleic acids and thera peutic agents, into the interior of cells by administering to …

The present invention relates, in part, to methods and compositions for needleless delivery
of macromolecules to a Subject. In one aspect, the methods and compositions involve …

A 6LX 9/27(2006.01) A63L/7II(2006.01) A63L/7056(2006.01) A6II 3/522(2006.01) A6II
3L/25(2006.01) A 6LX 3L/705(2006.01) A638/2(2006.01) A6IP3L/2(2006.01)(52) US Cl …