Background Melatonin, as a free radical scavenger exhibiting genomic actions, regulates
the antioxidant genes expression and apoptosis mechanisms. In polycystic ovary syndrome …

The preservation of ovaries beyond 7 h dramatically decreases the developmental potential
of oocytes to reach the blastocyst stage during in vitro embryo production. Here we …

Abstract Mammalian Target of Rapamycin (mTOR) signaling pathway has important roles in
the regulation of puberty onset, gonadotropin secretion, follicular development and …

The purpose of oocyte in vitro maturation is generation of mature oocytes that could support
future development. Efforts have been made to enhance oocyte developmental competence …

High-quality eggs are essential for the sustainability of commercial aquaculture production.
Melatonin is a potent candidate for regulating the growth and maturation of oocytes …

In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …

Oxidative stress has been recognized as one of the causal mediators of female infertility by
affecting the oocyte quality and early embryo development. Improving oxidative stress is …

Objective We evaluated the effect of melatonin, as a potent antioxidant agent, on glutathione
(GSH) and reactive oxygen species (ROS) levels, as well as histone H3 lysine 9 (H3K9), and …

Background: It is important to protect oocytes and embryos from oxidative stress in the
culture medium. Melatonin has been shown to be a direct free radical scavenger. Objective …

Poor‐quality oocytes (those with 1–2 layers of cumulus cells) typically possess low meiotic
competence and development. Prolonging the duration of in vitro maturation (IVM; 52 hr) …