Initiating drug use during adolescence increases the risk of developing addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …

The fine arrangement of neuronal connectivity during development involves the coordinated
action of guidance cues and their receptors. In adolescence, the dopamine circuitry is still …

The development of the dopamine input to the medial prefrontal cortex occurs during
adolescence and is a process that is vulnerable to disruption by stimulant drugs such as …

Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

A dramatic maturational process ongoing in adolescence is prefrontal cortex development,
including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal …

During the pubertal period the mesocortical dopamine (DA) system undergoes substantial
reorganization of neuronal connectivity and functional refinement. Netrins are guidance …

Changes in mesocorticolimbic dopamine (DA) neurons and their target cells can be induced
throughout life and are important determinants of individual differences in susceptibility to …

Rationale Netrin-1 guidance cues contribute to amphetamine-induced plasticity of the adult
mesocorticolimbic dopamine system in rodents. The netrin-1 receptor, deleted in colorectal …

The guidance cue receptor DCC controls mesocortical dopamine development in
adolescence. Repeated exposure to an amphetamine regimen of 4 mg/kg during early …

Background Dopaminergic input to the prefrontal cortex (PFC) increases throughout
adolescence and, by establishing precisely localized synapses, calibrates cognitive …