Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny
Paternal environmental perturbations including exposure to drugs of abuse can produce
profound effects on the physiology and behavior of offspring via epigenetic modifications …
profound effects on the physiology and behavior of offspring via epigenetic modifications …
Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain
J Knabbe, J Protzmann, N Schneider… - Proceedings of the …, 2022 - National Acad Sciences
Alcohol intoxication at early ages is a risk factor for the development of addictive behavior.
To uncover neuronal molecular correlates of acute ethanol intoxication, we used stable …
To uncover neuronal molecular correlates of acute ethanol intoxication, we used stable …
Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour
Background: The monoaminergic transmitters dopamine (DA), noradrenaline (NE) and
serotonin (5-HT) modulate cerebral functions via their extensive effects in the brain …
serotonin (5-HT) modulate cerebral functions via their extensive effects in the brain …
Cocaine inhibits NGF-induced PC12 cells differentiation through D1-type dopamine receptors
DA Zachor, JF Moore, C Brezausek, A Theibert… - Brain research, 2000 - Elsevier
In utero cocaine exposure can adversely affect CNS development. Previous studies showed
that cocaine inhibits neuronal differentiation in a dose-dependent fashion in nerve growth …
that cocaine inhibits neuronal differentiation in a dose-dependent fashion in nerve growth …
[HTML][HTML] Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine
Drugs of abuse increase extracellular concentrations of dopamine in the nucleus
accumbens (NAc), resulting in transcriptional alterations that drive long-lasting cellular and …
accumbens (NAc), resulting in transcriptional alterations that drive long-lasting cellular and …
Social deprivation enhances VTA synaptic plasticity and drug-induced contextual learning
LR Whitaker, M Degoulet, H Morikawa - Neuron, 2013 - cell.com
Drug addiction is driven, in part, by powerful drug-related memories. Deficits in social life,
particularly during adolescence, increase addiction vulnerability. Social isolation in rodents …
particularly during adolescence, increase addiction vulnerability. Social isolation in rodents …
Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling
L Cavalleri, E Merlo Pich, MJ Millan, C Chiamulera… - Molecular …, 2018 - nature.com
Among neurobiological mechanisms underlying antidepressant properties of ketamine,
structural remodeling of prefrontal and hippocampal neurons has been proposed as critical …
structural remodeling of prefrontal and hippocampal neurons has been proposed as critical …
The neuroscience of addiction
N Volkow, TK Li - Nature neuroscience, 2005 - nature.com
The burden of substance abuse and addiction to society is enormous, with an estimated
annual economic impact in the United States of approximately half a trillion dollars arising …
annual economic impact in the United States of approximately half a trillion dollars arising …
The Netrin-1/DCC guidance cue pathway as a molecular target in depression: translational evidence
The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …
toward the prefrontal cortex during adolescence and in the maturational organization and …