The reinforcing and rewarding properties of cocaine are attributed to its ability to increase
dopaminergic transmission in nucleus accumbens (NAc). This action reinforces drug taking …

Early adverse experience is a well-known risk factor for addictive behaviors later in life. Drug
addiction typically manifests during adolescence in parallel with the later-developing …

The prefrontal cortex (PFC) is divided into subregions, including the medial and orbital
prefrontal cortices. Dopamine connectivity in the medial PFC (mPFC) continues to be …

Adult neural plasticity engages mechanisms that change synapse structure and function, yet
many of the underlying events bear a striking similarity to processes that occur during the …

Adolescence is a period of heightened vulnerability both to addictive behaviors and drug-
induced brain damage. Yet, only limited information exists on the brain mechanisms …

The abuse potential of ketamine limits its clinical application, but the precise mechanism
remains largely unclear. Here we discovered that ketamine significantly remodels the …

Chronic exposure to drugs of abuse induces countless modifications in brain physiology.
However, the neurobiological adaptations specifically associated with the transition to …

Drug-evoked synaptic plasticity is observed at many synapses and may underlie
behavioural adaptations in addiction. Mechanistic investigations start with the identification …

Early binge-like alcohol drinking may promote the development of hazardous intake.
However, the enduring cellular alterations following the first experience with alcohol …

Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter
transcriptional programs believed to promote long-lasting synaptic and behavioral …