[HTML][HTML] OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α
JH Baek, PC Mahon, J Oh, B Kelly, B Krishnamachary… - Molecular cell, 2005 - cell.com
Abstract Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen
homeostasis in metazoan species. HIF-1 mediates changes in gene transcription in …
homeostasis in metazoan species. HIF-1 mediates changes in gene transcription in …
Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1α
DA Chan, PD Sutphin, SE Yen… - Molecular and cellular …, 2005 - Taylor & Francis
Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible
factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains …
factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains …
Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1α is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association …
N Sang, J Fang, V Srinivas… - Molecular and cellular …, 2002 - Am Soc Microbiol
Hypoxia-inducible factor 1 complex (HIF-1) plays a pivotal role in oxygen homeostasis and
adaptation to hypoxia. Its function is controlled by both the protein stability and the …
adaptation to hypoxia. Its function is controlled by both the protein stability and the …
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
PC Mahon, K Hirota, GL Semenza - Genes & development, 2001 - genesdev.cshlp.org
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …
Leu‐574 of human HIF‐1α is a molecular determinant of prolyl hydroxylation
Y Kageyama, M Koshiji, KKW To, YM Tian… - The FASEB …, 2004 - Wiley Online Library
ABSTRACT Hypoxia‐inducible factor (HIF)‐1α, a master regulator of oxygen homeostasis,
regulates genes crucial for cell growth and survival. In normoxia, HIF‐1α is constantly …
regulates genes crucial for cell growth and survival. In normoxia, HIF‐1α is constantly …
[HTML][HTML] Suppression of hypoxia-inducible factor 1α (HIF-1α) transcriptional activity by the HIF prolyl hydroxylase EGLN1
The cellular response to hypoxia is, at least in part, mediated by the transcriptional
regulation of hypoxia-responsive genes involved in balancing the intracellular ATP …
regulation of hypoxia-responsive genes involved in balancing the intracellular ATP …
[HTML][HTML] HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia
E Berra, E Benizri, A Ginouvès, V Volmat, D Roux… - The EMBO …, 2003 - embopress.org
Hypoxia‐inducible factor (HIF), a transcriptional complex conserved from Caenorhabditis
elegans to vertebrates, plays a pivotal role in cellular adaptation to low oxygen availability …
elegans to vertebrates, plays a pivotal role in cellular adaptation to low oxygen availability …
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1α, leading to its oxygen-independent degradation
MY Koh, BG Darnay, G Powis - Molecular and cellular biology, 2008 - Taylor & Francis
The hypoxia-inducible factor 1α (HIF-1α) is the master regulator of the cellular response to
hypoxia. A key regulator of HIF-1α is von Hippel-Lindau protein (pVHL), which mediates the …
hypoxia. A key regulator of HIF-1α is von Hippel-Lindau protein (pVHL), which mediates the …
[HTML][HTML] HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation
E Berra, DE Richard, E Gothié, J Pouysségur - FEBS letters, 2001 - Elsevier
Hypoxia-inducible factor-1α (HIF-1α) plays a central role in oxygen homeostasis. In
normoxia, HIF-1α is a short lived protein, whereas hypoxia rapidly increases HIF-1α protein …
normoxia, HIF-1α is a short lived protein, whereas hypoxia rapidly increases HIF-1α protein …
A compendium of proteins that interact with HIF-1α
GL Semenza - Experimental cell research, 2017 - Elsevier
Abstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …