Using a rat tail-flick analgesic assay that uses a cold water-ethylene glycol mixture (-10
degrees C) as the noxious stimulus, we have been able to demonstrate a dose-related …

Abstract Tebanicline (ABT-594), an analogue of epibatidine, exhibits potent antinociceptive
effects and high affinity for the nicotinic acetylcholine receptor in the central nervous system …

The present studies investigated behavioral and neurochemical aspects of the
noradrenergic and serotonergic nervous systems in streptozotocin-induced diabetic mice …

Morphine caused a dose-related antinociception in early phase and late phase of formalin
test in mice. The D2 dopamine agonist quinpirole, but not the D1 dopamine agonist SKF …

Intracerebroventricular administration of muscimol, a potent GABA-receptor agonist,
counteracted the antinociceptive effect of morphine or β-endorphin in rats as measured by …

In this study, we examined whether Sprague-Dawley rats obtained from two different
vendors, Harlan and Sasco, differ with respect to the types of alpha-2 adrenoceptors in the …

The effects of intrathecal administration of nimodipine or omega-conotoxin GVIA (L-and N-
type calcium channel blockers, respectively) alone or followed by DAMGO, DADLE or …

Systemic (sc) administration of α 2 agonists clonidine (25–100 μg/kg) or guanfacine (50–400
μg/kg) elicited antinociception as assessed by the cat tail-flick model and potentiated in a …

Intraspinal administration of alpha 2 adrenergic agonists produces analgesia, but clinical
application of these agents is limited by dose-dependent sedation and hypotension …

The effects of dexamethasone pretreatment on clonidine-induced antinociception and
locomotor hypoactivity were investigated in mice. In the hot-plate and the tail-flick tests …