Methods Intrathecal injections. Intrathecal injections were performed following the protocol
of Hylden and Wilcox (1983). Unanesthetized mice were injected between the L5 or L area …

This study was designed primarily to relate the antinociceptive and hemodynamic effects of
clinically available α 2-adrenoceptor agonists to their binding affinity for α 2-adrenoceptors …

Phenoxybenzamine was antinociceptive in the mouse tail electrical stimulation assay
(ED50, 36.8 mg/kg) with a peak effect at 2 1 2 hours after subcutaneous injection. Naloxone …

It has been reported that opioid receptor antagonist can induce antinociception in several
nociceptive tests. In the intraplantar formalin pain model, however, opioid antagonist …

The effects of various doses of the α-2 adrenoceptor agonist clonidine administered
systemically (30, 50 and 100 μg/kg iv), were investigated on the vocalization threshold to …

1. Gabaergic and cholinergic mediation in the antinociceptive effect of taurine has been
investigated in mice (acetic acid test) and rats (tail-flick test). 2. Scopolamine sulfate and …

Medetomidine, a new α 2-adrenoceptor agonist produced dose-depndent (30–100 μg/kg ip)
analgesia in the formalin test in rats, and this effect was reversed by atipamezole (1 mg/kg) …

The naked mole-rat (Heterocephalus glaber) is a promising animal model for the study of
pain mechanisms, therefore a thorough characterization of this species is essential. The aim …

The mechanism by which muscarinic or nicotinic agonists produce antinociception has been
the subject of several studies. In the present investigation, we used intrathecal …

It has been shown that a number of sympathomimetic drugs, administered subcutaneously,
have potent antinociceptive activity in the mouse abdominal constriction test. These drugs …