Blood malignancies arise from the dysregulation of haematopoiesis. The type of blood cell
and the specific order of oncogenic events initiating abnormal growth ultimately determine …

Leukemia is caused by the accumulation of multiple genomic lesions in hematopoietic
precursor cells. However, how these events cooperate during oncogenic transformation …

HoxA10 is a homeodomain transcription factor that is maximally expressed in myeloid
progenitor cells. An increase in HoxA10 expression correlates with poor prognosis in human …

Background HOXA family genes were crucial transcription factors involving cell proliferation
and apoptosis. While few studies have focused on HOXA10 in AML. We aimed to investigate …

Aberrant HOXA9 expression is a hallmark of most aggressive acute leukemias, notably
those with KMT2A (MLL) gene rearrangements. HOXA9 overexpression not only predicts …

Ectopic expression of the oncogenic transcription factor HoxA9 is a major cause of acute
myeloid leukemia (AML). Here, we demonstrate that HoxA9 is a specific substrate of granule …

Deregulated expression of Hox genes such as HoxA9 is associated with development of
myeloproliferative disorders and leukemia and indicates a poor prognosis. To investigate …

HOXA9 deregulation underlies a large subset of aggressive acute leukemias.
Understanding the mechanisms regulating the expression and activity of HOXA9, along with …

Background Although the biological insight of acute myeloid leukemia (AML) has increased
in the past few years, the discovery of novel discriminative biomarkers remains of utmost …

Dysregulation of the oncogenic transcription factor HOXA9 is a prominent feature for most
aggressive acute myeloid leukemia cases and a strong indicator of poor prognosis in …