Background: Celecoxib was shown to regress colorectal adenomas in familial adenomatous
polyposis (FAP) patients relative to placebo. To address the mechanism of polyp regression …

Colorectal cancer is one of the commonest malignancies worldwide. Recently, there has
been much speculation regarding the role of cyclooxygenase-2 (COX-2) suppression in …

Aberrant crypt foci (ACF) are the earliest visible neoplastic lesions in the colorectum. The
natural history of these lesions and their role in the adenoma-carcinoma sequence are …

Non–small cell lung cancer is the primary cause of cancer-related death in Western
countries. One important approach taken to address this problem is the development of …

Chemoprevention began to be considered as a potential strategy for lowering the incidence
of cancer and cancer‐related deaths in the 1970s. For clinical chemoprevention trials …

BACKGROUND & AIMS: Variants in the cytochrome P450 2C9 (CYP2C9) gene are
associated with impaired metabolism of celecoxib. We examined the influence of CYP2C9 …

Mortality in patients with advanced colorectal cancer (CRC) remains high. Epidemiologic
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …

Background: Colorectal cancer (CRC) is one of the most common cancers worldwide and a
prevalent cause of morbidity and mortality. CRC has a natural history of transition from a …

Purpose: To examine the benefits and harms of nonaspirin (non-ASA) nonsteroidal anti-
inflammatory drugs (NSAIDs) and cyclooxygenase (COX-2) inhibitors for the prevention of …

Epidemiological and animal studies suggest that nonsteroidal anti-inflammatory drugs
(NSAIDs) may reduce colon cancer risk. NSAIDs nonselectively inhibit both the constitutive …