THE LANCET Oncology Vol 4 October 2003 http://oncology. thelancet. com 606 anti-
inflammatory prostaglandins (PGD2 and PGF2α) and a member of the cyclopentenone …

Chronic inflammation is a tissue-specific process implicated in several diseases of an aging
population, including cancer, cardiovascular disease, and arthritis. Cyclooxygenase-2 (COX …

OBJECTIVES: Celecoxib is approved as an adjunctive chemopreventive agent in adults with
familial adenomatous polyposis (FAP). Its safety and efficacy for colorectal polyps in children …

Background & Aims: Aspirin and nonsteroidal anti-inflammatory drugs have been reported to
protect against the development of colorectal cancer. Because adenomas are precursors to …

Clinical trial data have prompted questions about the degree to which patients and their
physicians should consider an increased risk of cardiovascular or cerebrovascular events …

Importance Aspirin and cyclooxygenase 2 (COX-2) inhibitors have been associated with a
reduced risk of colorectal polyps and cancer in observational and randomized studies. The …

Colorectal adenomatous polyps are thought to be precursors of colorectal cancer. This
article reviews the evidence for the adenoma-carcinoma sequence and possible …

Cyclooxyenase (COX)-2 selective inhibitors were devel-oped to create a new class of
nonsteroidal antiinflammatory drugs (NSAIDs) with properties similar to those of …

Nonsteroidal anti-inflammatory drugs have potential for use in the prevention and/or
treatment of colorectal cancer. We have studied the cytotoxic effect of a specific COX-2 …

Large bowel cancer is not only the third most frequent cancer in the world but is one of the
most common human malignancies in Western countries, including North America. In recent …