Objectives Chemoprevention is a promising strategy to inhibit carcinoma before invasive
tumors develop, but a new molecular target is desirable. Celecoxib is a newly developed …

Several studies have suggested that cyclooxygenase-2 (COX-2) expression is associated
with parameters of aggressive breast cancer, including large tumor size, positive axillary …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

Parecoxib, Valdecoxib, and Cardiovascular Risk | Circulation Science Volunteer Warning
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Aim. The present meta-analysis attempted to assess whether an unfavourable
cardiovascular risk profile could be identified in the case of two COX2 selective inhibitors …

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can be regarded as an
effective approach for cancer chemoprevention, as demonstrated by a bulk of clinical and …

Cyclooxygenase-2 (COX-2) is associated with tumour promotion, inhibition of apoptosis,
angiogenesis and metastasis. Celecoxib, a selective COX-2 inhibitor was investigated, in …

Objective: Further understand the safety profile of celecoxib and provide safety information
for important adverse events (AEs). Methods: Analysis of randomized controlled trials from …

Abstract Purpose: Selective cyclooxygenase-2 (COX-2) inhibitors may suppress
carcinogenesis by both COX-2-dependent and COX-2-independent mechanisms. The …

OBJECTIVE: The aim of this study was to assess the rate of upper gastrointestinal (UGI)
ulcer complications (bleeding, perforation, or gastric outlet obstruction) associated with …