Regulatory T cells engineered with TCR signaling–responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter
Adoptive cell transfer of ex vivo expanded regulatory T cells (Tregs) has shown immense
potential in animal models of auto-and alloimmunity. However, the effective translation of …
potential in animal models of auto-and alloimmunity. However, the effective translation of …
Antigen-and epitope-delivering nanoparticles targeting liver induce comparable immunotolerance in allergic airway disease and anaphylaxis as nanoparticle …
The targeting of natural tolerogenic liver sinusoidal endothelial cells (LSEC) by
nanoparticles (NPs), decorated with a stabilin receptor ligand, is capable of generating …
nanoparticles (NPs), decorated with a stabilin receptor ligand, is capable of generating …
Gel Phase 1,2-Distearoyl-sn-glycero-3-phosphocholine-Based Liposomes Are Superior to Fluid Phase Liposomes at Augmenting Both Antigen Presentation on Major …
K Norling, V Bernasconi… - ACS infectious …, 2019 - ACS Publications
Lipid-based nanoparticles have in recent years attracted increasing attention as
pharmaceutical carriers. In particular, reports of them having inherent adjuvant properties …
pharmaceutical carriers. In particular, reports of them having inherent adjuvant properties …
Antigen-specific immune decoys intercept and exhaust autoimmunity to prevent disease
Relapsing-remitting patterns of many autoimmune diseases such as multiple sclerosis (MS)
are perpetuated by a recurring circuit of adaptive immune cells that amplify in secondary …
are perpetuated by a recurring circuit of adaptive immune cells that amplify in secondary …
Preparation of glycopeptide-modified pH-sensitive liposomes for promoting antigen cross-presentation and induction of antigen-specific cellular immunity
Cross-presentation, exogenous antigen presentation onto major histocompatibility complex
class I molecules on antigen presenting cells, is crucially important for inducing antigen …
class I molecules on antigen presenting cells, is crucially important for inducing antigen …
Retinoic acid-containing liposomes for the induction of antigen-specific regulatory T cells as a treatment for autoimmune diseases
The current treatment of autoimmune and chronic inflammatory diseases entails systemic
immune suppression, which is associated with increased susceptibility to infections. To …
immune suppression, which is associated with increased susceptibility to infections. To …
Nanoparticle dose and antigen loading attenuate antigen‐specific T‐cell responses
Immune‐mediated hypersensitivities such as autoimmunity, allergy, and allogeneic graft
rejection are treated with therapeutics that suppress the immune system, and the lack of …
rejection are treated with therapeutics that suppress the immune system, and the lack of …
Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models
X Chen, X Yang, P Yuan, R Jin, L Bao, X Qiu… - Science Translational …, 2021 - science.org
The therapeutic goal for autoimmune diseases is disease antigen-specific immune tolerance
without nonspecific immune suppression. However, it is a challenge to induce antigen …
without nonspecific immune suppression. However, it is a challenge to induce antigen …
Suppression of immune response by antigen-modified liposomes encapsulating model agents: a novel strategy for the treatment of allergy
K Ichikawa, T Asai, K Shimizu, S Yonezawa… - Journal of controlled …, 2013 - Elsevier
A specific antigen-sensitized animal has antigen-specific immune cells that recognize the
antigen. Therefore, an antigen-modified drug carrier would be recognized by the immune …
antigen. Therefore, an antigen-modified drug carrier would be recognized by the immune …
[HTML][HTML] Co-encapsulation of antigen and Toll-like receptor ligand in cationic liposomes affects the quality of the immune response in mice after intradermal …
Enhanced immunogenicity of subunit antigens can be achieved by antigen encapsulation in
liposomes and the addition of immune potentiators. In this study we co-encapsulated …
liposomes and the addition of immune potentiators. In this study we co-encapsulated …