Abstract Alternatively-activated, M2-like tumor-associated macrophages (TAM) strongly
contribute to tumor growth, invasiveness and metastasis. Technologies to disable the pro …

Epitope density has a profound impact on B cell responses to particulate Ags, the molecular
mechanisms of which remain to be explored. To dissect the role of epitope density in this …

Nanovaccines are of increasing scrutiny due to their plasticity in size, composition, and
surface properties to enhance antigenicity. However, inevitable absorption of plasma …

Siglec-8 is an inhibitory receptor expressed on eosinophils and mast cells. In this study, we
took advantage of a novel Siglec-8 transgenic mouse model to assess the impact of …

Increasing prevalence of allergic and autoimmune diseases urges clinicians and
researchers to search for new and efficient treatments. Strategies that activate antigen …

Delivery of antigenic protein to the cytosol of antigen-presenting cells (APCs), such as
macrophages (MΦ) and dendritic cells (DCs), is required for an efficient CD8 T-cell …

Lymph nodes (LNs) are peripheral lymphoid organs essential for vaccine-induced immune
responses. Although cationic liposomes have been documented as a novel adjuvant and …

Dendritic cells (DCs) are key antigen presenting cells that have the unique ability to present
antigens on MHC molecules, which can lead to either priming or suppression of T cell …

Since liposomes are known as strong adjuvants, we attempted to use liposomes in
immunotherapy as adjuvants, and to achieve desensitization in pre-sensitized mice. At first …

Autoimmune conditions, allergies, and immunogenicity against therapeutic proteins are
initiated by the unwanted immune response against self and non-self proteins. The …