[HTML][HTML] Developing Wolbachia-based disease interventions for an extreme environment

PA Ross, S Elfekih, S Collier, MJ Klein, SS Lee… - PLoS …, 2023 - journals.plos.org
Aedes aegypti mosquitoes carrying self-spreading, virus-blocking Wolbachia bacteria are
being deployed to suppress dengue transmission. However, there are challenges in …

[HTML][HTML] Wolbachia Infections Are Virulent and Inhibit the Human Malaria Parasite Plasmodium Falciparum in Anopheles Gambiae

GL Hughes, R Koga, P Xue, T Fukatsu… - PLoS …, 2011 - journals.plos.org
Endosymbiotic Wolbachia bacteria are potent modulators of pathogen infection and
transmission in multiple naturally and artificially infected insect species, including important …

[HTML][HTML] Aedes aegypti insecticide resistance underlies the success (and failure) of Wolbachia population replacement

GA Garcia, AA Hoffmann, R Maciel-de-Freitas… - Scientific reports, 2020 - nature.com
Mosquitoes that carry Wolbachia endosymbionts may help control the spread of arboviral
diseases, such as dengue, Zika and chikungunya. Wolbachia frequencies systematically …

Using Wolbachia for dengue control: insights from modelling

I Dorigatti, C McCormack, G Nedjati-Gilani… - Trends in …, 2018 - cell.com
Dengue is the most common arboviral infection of humans, responsible for a substantial
disease burden across the tropics. Traditional insecticide-based vector-control programmes …

[HTML][HTML] Replacing a Native Wolbachia with a Novel Strain Results in an Increase in Endosymbiont Load and Resistance to Dengue Virus in a Mosquito Vector

G Bian, G Zhou, P Lu, Z Xi - PLoS Neglected Tropical Diseases, 2013 - journals.plos.org
Wolbachia is a maternally transmitted endosymbiotic bacterium that is estimated to infect up
to 65% of insect species. The ability of Wolbachia to both induce pathogen interference and …

Harnessing mosquito–Wolbachia symbiosis for vector and disease control

K Bourtzis, SL Dobson, Z Xi, JL Rasgon, M Calvitti… - Acta tropica, 2014 - Elsevier
Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major
vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of …

Wolbachia-mediated virus blocking in the mosquito vector Aedes aegypti

G Terradas, EA McGraw - Current opinion in insect science, 2017 - Elsevier
Highlights•Wolbachia-mediated blocking is density dependent in most associations and
tends to be greater in novel infections.•Immune priming is commonly seen in novelly …

[HTML][HTML] Viral RNA is a target for Wolbachia-mediated pathogen blocking

T Bhattacharya, ILG Newton, RW Hardy - PLoS Pathogens, 2020 - journals.plos.org
The ability of the endosymbiont Wolbachia pipientis to restrict RNA viruses is presently
being leveraged to curb global transmission of arbovirus-induced diseases. Past studies …

Mechanisms of horizontal cell-to-cell transfer of Wolbachia spp. in Drosophila melanogaster

PM White, JE Pietri, A Debec, S Russell… - Applied and …, 2017 - Am Soc Microbiol
Wolbachia is an intracellular endosymbiont present in most arthropod and filarial nematode
species. Transmission between hosts is primarily vertical, taking place exclusively through …

[HTML][HTML] The spread of Wolbachia through mosquito populations

FM Jiggins - PLoS biology, 2017 - journals.plos.org
In many regions of the world, mosquito-borne viruses pose a growing threat to human
health. As an alternative to traditional control measures, the bacterial symbiont Wolbachia …