SIRT1 belongs to the mammalian sirtuin family and plays an important role in deacetylating
histone and nonhistone proteins. It is reported that SIRT1 is associated with tumor …

Background SIRT1 is a member of the mammalian sirtuin family with the ability to
deacetylate histone and nonhistone proteins. The correlation between SIRT1 expression …

Abstract Sirtuin1 (SIRT1) belongs to the mammalian sirtuin family and plays an important
role in deacetylating histones and non-histones. SIRT1 is associated with tumor metastasis …

Pulmonary metastasis is the leading cause of mortality in patients with osteosarcoma;
however, the underlying mechanism remains unclear. The NAD+-dependent deacetylase …

Melanoma is highly metastatic, and understanding of its molecular mechanism is urgently
needed for the development of therapeutic targets and prognostic assessment for metastatic …

SIRT6, is a member of the NAD‑dependent sirtuin family of enzymes, and has been reported
as a novel tumor suppressor gene or oncogene, dependent on the type of cancer. However …

Osteosarcomas (OS) are highly metastatic and usually lead to poor outcomes. Epithelial-
mesenchymal transition (EMT) is reported to be a critical event in metastasis. SIRT2 exerts …

Osteosarcoma is the most common malignant bone cancer that mainly affects children and
young adults. Recently, the NAD+‐dependent deacetylase, sirtuin 1 (SIRT1), has been …

The epithelial–mesenchymal transition (EMT) is a highly networked cellular process which
involves cell transition from the immotile epithelial to the motile mesenchymal phenotype …

Distant metastasis and local recurrence are still the major causes for failure of treatment in
patients with ovarian carcinoma (OC), making it urgent to further elicit the molecular …