Background Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in lung cancer
metastasis. The class III deacetylase sirtuin 1 (SIRT1) possesses both pro-and …

As a member of the sirtuins family, also called Class III histone deacetylases (HDACs),
SIRT6 has many catalytic enzyme activities and plays a pivotal role in biological processes …

Localized in the mitochondria, SIRT4 is a nicotinamide adenine dinucleotide (NAD+)-
dependent adenosine diphosphate (ADP)-ribosyltransferase and is one of the least …

Abstract Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological
processes through deacetylation of histone and nonhistone proteins. However, the …

SIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma
(PDAC) and Promotes Migration and Growth of PDAC Cells - PMC Back to Top Skip to main …

Abstract Sirtuin 2 (SIRT2) belongs to the sirtuins family. It exists in many tissues and organs
of the human body and regulates a wide range of biological functions. Studies have found …

Metastasis is responsible for over 90% of cancer-associated mortality. In epithelial
carcinomas, a key process in metastatic progression is the epigenetic reprogramming of an …

Background SIRT4, a protein localized in the mitochondria, is one of the least characteristic
members of the sirtuin family. It is known that SIRT4 has deacetylase activity and plays a role …

Hepatocellular carcinoma is one of the leading causes for cancer-related mortality
worldwide. SIRT3 may function as either oncogene or tumor suppressor in a panel of …

Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member
of sirtuin family, plays a dual role either in cancer promotion or suppression. There is no …