Abstract Sirtuin 1 (SIRT1), originally identified as a longevity gene, is induced by caloric
restriction, and regulates various cellular functions including DNA repair, cell survival and …

The NAD+-dependent deacetylase, sirtuin 1 (SIRT1), has been recently been suspected to
have a role in tumorigenesis. We investigated the expression of SIRT1 in pancreatic cancer …

SIRT7 is a member of the sirtuin family of proteins that are known to be associated with
tumor development. However, the functional roles and molecular mechanisms underlying …

The role of autophagy in cancer is context-dependent. In the present study, we aimed to
investigate the regulator and underlying mechanism of autophagy. We found that a sirtuin …

The NAD-dependent deacetylase sirtuin 1 (SIRT1), a member of the mammalian sirtuin
family, plays a pivotal role in deacetylating histone and nonhistone proteins. Recently, it has …

Seven Sirtuin family members (SIRT1-7), comprising a family of NAD+-dependent protein
deacetylases and ADP-ribosyltransferases, are key proteins that regulate multiple …

Abstract SIRT1, an NAD+-dependent histone/protein deacetylase, has diverse physiological
actions. Recent studies have demonstrated that SIRT1 is overexpressed in colorectal …

Abstract Sirtuin 7 (Sirt7) is a member of the sirtuin protein family and is implicated in various
carcinomas; however, the function of Sirt7 in colorectal carcinoma (CRC) remains unclear …

Sirtuin 1 (SIRT1), an NAD+‐dependent histone/protein deacetylase, has multifaceted
functions in various biological events such as inflammation, aging, and energy metabolism …

Sirtuins are NAD+ dependent deacetylases and/or ADP-ribosyl transferases active on
histone and non-histone substrates. The first sirtuin was discovered as a transcriptional …