OBJECTIVE: Sirtuins (SIRT) are NAD+-dependent protein deacetylases that are involved in
the regulation of cancer-associated pathways. However, the biological role of these …

Chordoma is a relatively rare and locally aggressive malignant tumor. Sirtuin (SIRT) 5 plays
pivotal roles in various tumors, but the role of SIRT5 in chordoma has not been found. This …

The mitochondrial deacetylase SIRT3 plays a pivotal role in the initiation and the
progression of certain cancers acting as an oncogene. However, in others it acts anti …

Purpose: Sirtuins play an important role in cancer development. Sirt7, as a member of this
family, is frequently overexpressed in certain carcinomas, but the oncogenic mechanism is …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths globally.
Incidence rates are steadily increasing, creating an unmet need for new therapeutic options …

Endometrial cancer (EC) constitutes a common female genital tract tumor with a rising
incidence rate. Sirtuin 1 (SIRT1) is a member of histone deacetylase, which extensively …

OBJECTIVE: Sirtuins family are defined as class III histone deacetylases (HDACs). Recently,
mammalian silent information regulator two 4 (SIRT4) has been reported to be a tumor …

SIRT1 is the human orthologue of SIR2, a conserved NAD-dependent protein deacetylase
that regulates longevity in yeast and in Caenorhabditis elegans. Overexpression of SIRT1 in …

Background Epithelial-to-mesenchymal transition (EMT) contributes to the invasion and
metastasis of epithelial tumors. Sirtuin 6 (SIRT6), an NAD-dependent deacetylase, is known …

Non‑small cell lung cancer (NSCLC) is one of the most devastating cancer types, accounting
for> 80% of lung cancer cases. The median relative survival time of patients with NSCLC is< …