Understanding the fiber-type specification and metabolic switch in skeletal muscle provides
insights into energy metabolism in physiology and diseases. Here, we show that miR-182 is …

MicroRNAs have emerged as important regulators of glucose and lipid metabolism in
several tissues; however, their role in skeletal muscle remains poorly characterized. We …

Understanding the regulation of insulin signalling in tissues provides insights into
carbohydrate and lipid metabolism in physiology and disease. Here we show that hepatic …

The role of microRNAs in metabolic diseases has been recognized and modulation of them
could be a promising strategy to treat obesity and obesity-related diseases. The major …

Background Exercise mimetics is a proposed class of therapeutics that specifically mimics or
enhances the therapeutic effects of exercise. Muscle glycogen and lactate extrusion are …

In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted
insulin; however, the pathways governing this adaptive response are not entirely …

Skeletal muscle is a highly adaptable tissue and remodels in response to exercise training.
Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from …

This study investigated miR‐148b as a potential physiological actor of physical inactivity‐
induced effects in skeletal muscle. By using animal and human protocols, we demonstrated …

Background The regulation of microRNAs (miRNAs) at different stages of the progression of
type 2 diabetes mellitus (T2DM) and their role in glucose homeostasis was investigated …

Skeletal muscle is composed of different myofiber types that preferentially use glucose or
lipids for ATP production. How fuel preference is regulated in these post-mitotic cells is …