Polyvinylpyrrolidone-coated gold nanoparticles inhibit endothelial cell viability, proliferation, and ERK1/2 phosphorylation and reduce the magnitude of endothelial …

T Mohamed, S Matou-Nasri, A Farooq… - International journal …, 2017 - Taylor & Francis
Background Gold nanoparticles (AuNPs) demonstrate clinical potential for drug delivery and
imaging diagnostics. As AuNPs aggregate in physiological fluids, polymer-surface …

[HTML][HTML] Synthesis of functionalized 10-nm polymer-coated gold particles for endothelium targeting and drug delivery

MJ Cheng, P Prabakaran, R Kumar… - Journal of …, 2018 - pmc.ncbi.nlm.nih.gov
Gold nanoparticles (AuNPs) have been used extensively in medical research due to their
size, biocompatibility, and modifiable surface. Specific targeting and drug delivery are some …

Gold nanoparticle interactions with endothelial cells cultured under physiological conditions

C Freese, L Anspach, RC Deller, SJ Richards… - Biomaterials …, 2017 - pubs.rsc.org
PEGylated gold nanoparticles (AuNPs) have an extended circulation time after intravenous
injection in vivo and exhibit favorable properties for biosensing, diagnostic imaging, and …

Uptake of gold nanoparticles in primary human endothelial cells

H Klingberg, LB Oddershede, K Loeschner… - Toxicology …, 2015 - academic.oup.com
Gold nanoparticles (AuNPs) are relevant in nanomedicine for drug delivery in the vascular
system, where endothelial cells are the first point of contact. We investigated the uptake of …

Gold nanoparticles compromise TNF-α-induced endothelial cell adhesion molecule expression through NF-κB and protein degradation pathways and reduce …

TH Lai, CH Chung, BH Chen, CF Hung… - Journal of …, 2016 - ingentaconnect.com
The aim of this study was to investigate the anti-inflammatory effects and mechanism of
action of the gold nanoparticles (AuNPs) on vascular injury. In vitro vascular endothelial cell …

Gold nanoparticles disrupt actin organization and pulmonary endothelial barriers

WE Sinclair, HH Chang, A Dan, PJA Kenis… - Scientific reports, 2020 - nature.com
This study explored the impact of gold nanoparticles on the metabolic activity and
morphology of human pulmonary endothelial cell monolayers. We developed a gold …

Nanoparticle size-specific actin rearrangement and barrier dysfunction of endothelial cells

Y Liu, N Rogel, K Harada, L Jarett, CH Maiorana… - …, 2017 - Taylor & Francis
In this work, we evaluated the impact of gold nanoparticles on endothelial cell behavior and
function beyond the influence on cell viability. Five types of gold nanoparticles were studied …

Evaluation of gold nanoparticles biocompatibility: a multiparametric study on cultured endothelial cells and macrophages

A Orlando, M Colombo, D Prosperi, F Corsi… - Journal of Nanoparticle …, 2016 - Springer
Colloidal gold nanoparticles (AuNPs) have been considered an established advanced tool
in biomedicine thanks to their physicochemical properties combined with nanoscale size …

Low-dose albumin-coated gold nanorods induce intercellular gaps on vascular endothelium by causing the contraction of cytoskeletal actin

Z Li, J Liu, K Ballard, C Liang, C Wang - Journal of Colloid and Interface …, 2023 - Elsevier
Cytotoxicity of nanoparticles, typically evaluated by biochemical-based assays, often
overlook the cellular biophysical properties such as cell morphology and cytoskeletal actin …

Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability …

CH Li, MK Shyu, C Jhan, YW Cheng… - Toxicological …, 2015 - academic.oup.com
Abstract Gold nanoparticles (Au-NPs) are being increasingly used as constituents in
cosmetics, biosensors, bioimaging, photothermal therapy, and targeted drug delivery. This …