The DSM-IV-TR distinguishes major depressive disorder (MDD) from normal sadness and
grief by requiring a certain duration and number of symptoms that cause impairment and …

This chapter shall address the classification of depressive disorders and its evolution over
the past 50 years. We shall present a brief historical overview of depressive disorders and …

The past 5 years have seen unprecedented advances in our knowledge about the
neurobiology of depression. Significant breakthroughs have been made in genomics …

The current definition of major depressive disorder (MDD) emerged from efforts to create
reliable diagnostic criteria for clinical and research use. However, despite decades of …

Depression presents a wide canvas for considering some approaches, issues, and
problems in the study of major categories of mental illness in the context of current …

INTRODUCTION The core elements ofwhatwenowcallmajor depressive disorder (MDD) are
as old as the history of humankind. Hippocrates (460-377 BC) described melancholia, a …

According to the World Health Organization, depression is among the leading cause of
disability worldwide with approximately 121 million people affected (http://www. who. int). It …

Hippocrates used “mania” and “melancholia” to describe depression around 400 BC. So,
clinicians, researchers, and philosophers have been challenged by depression for over a …

This article will heuristically overview some of the more recent conceptualizations of the
pathogenesis and pathophysiology of major depression as well as the functional changes in …

The progress of psychiatry over the past few years is impressive. That process, however, is
nonlinear and in this paper three developments in depression research are discussed and …