Background Genetic testing, to identify pathogenic or likely pathogenic variants in prostate
cancer, is valuable in guiding treatment decisions for men with prostate cancer and to inform …

Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

Significant progress has been made in genetic and genomic testing for prostate cancer
across the disease spectrum. Molecular profiling is increasingly relevant for routine clinical …

Background Prostate cancer is among the most heritable cancers, and clinical testing for
germline genetic variants based on ethnicity, disease features, and family history has …

Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …

Background Genetic counseling and germline testing have an increasingly important role for
patients with prostate cancer (PCa); however, recent data suggests they are underutilized …

Prostate cancer (PC) has the highest degree of genetic transmission of any form of
malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal …

Background Germline testing is recommended for all men with metastatic prostate cancer
(PCa), and for some with localized PCa meeting specific histologic or family history criteria …

BACKGROUND Prostate cancer has a significant heritable component, and rare deleterious
germline variants in certain genes can increase the risk of the disease. The aim of the …

Prostate cancer is the most commonly diagnosed cancer among men in the United States as
well as most Western countries. A significant proportion of men report having a positive …