The appropriateness of the recommended L-thyroxine dose (10-15 μg/kg/day) for the
treatment of congenital hypothyroidism has been questioned because of the risk of …

Objective Early diagnosis and treatment of congenital hypothyroidism (CH) and the
prevention of developmental retardation is the main goal of public health national screening …

Background and aims: The optimal dose of thyroxine (T4) in congenital hypothyroidism (CH)
during infancy is controversial. Higher doses lead to improvement in cognitive scores, but …

Neonatal thyroid screening programs were first im-plemented in the mid-to late 1970s to
detect congenital hypothyroidism (CH) as soon after birth as possible and begin therapy …

Congenital hypothyroidism (CH) is the most common cause of preventable cognitive
disability worldwide. Generally, it is produced by an alteration in the embryogenesis of the …

Congenital hypothyroidism (CH), detected in 1: 3500 to 1: 4000 newborns world-wide, is
one of the most common preventable causes of mental retardation if treated early (1). In the …

Objectives We designed a multicentre open prospective randomized trial to evaluate the risk-
benefit profile of two different initial treatment schemes with levothyroxine (L-T4), 10-12.5 …

We aim to determine long-term intellectual outcome of adolescents with early high-dose
treated congenital hypothyroidism (CH). Sixty-three prospectively followed children with CH …

Objective Thyroid hormones are essential for normal brain development. The aim of this
study is to assess if high concentration of thyroid stimulating hormone (TSH) that is below …

Background: Optimal treatment of children with congenital hypothyroidism (CHT) is still
debated. Our objective was to evaluate whether early undertreatment (UT) and …