Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway

Y Zhou, S Wang, T Wan, Y Huang, N Pang… - Free Radical Biology …, 2020 - Elsevier
Alcoholic liver disease (ALD) is a major cause of liver disease worldwide. In patients with
ALD, an increased level of hepatic inflammasome components was observed, together with …

Daucosterol Alleviates Alcohol− Induced Hepatic Injury and Inflammation through P38/NF− κB/NLRP3 Inflammasome Pathway

F Zhang, M Wang, Y Zha, J Zhou, J Han, S Zhang - Nutrients, 2023 - mdpi.com
Alcoholic liver disease (ALD) is caused by chronic excessive alcohol consumption, which
leads to inflammation, oxidative stress, lipid accumulation, liver fibrosis/cirrhosis, and even …

Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome

C Wu, Y Bian, B Lu, D Wang, NLB Azami, G Wei… - Journal of Translational …, 2022 - Springer
Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic
liver diseases and has become a huge public health issue worldwide. Inhibition of …

Chlorogenic acid ameliorated non-alcoholic steatohepatitis via alleviating hepatic inflammation initiated by LPS/TLR4/MyD88 signaling pathway

X Gu, M Wei, F Hu, H Ouyang, Z Huang, B Lu… - Chemico-Biological …, 2023 - Elsevier
Non-alcoholic steatohepatitis (NASH) is a severe pathological stage in non-alcoholic fatty
liver disease (NAFLD) and is generally recognized to be induced by chronic inflammation …

Caffeine inhibits NLRP3 inflammasome activation by downregulating TLR4/MAPK/NF-κB signaling pathway in an experimental NASH model

EE Vargas-Pozada, E Ramos-Tovar… - International Journal of …, 2022 - mdpi.com
Caffeine elicits protective effects against liver diseases, such as NASH; however, its
mechanism of action involving the pyrin domain-containing-3 (NLRP3) inflammasome …

Simultaneous modulation of NLRP3 inflammasome and Nrf2/ARE pathway rescues thioacetamide-induced hepatic damage in mice: role of oxidative stress and …

DK Dwivedi, GB Jena - Inflammation, 2022 - Springer
Chronic tissue injury resulting in fibrosis of multiple organs, responsible for one-third of the
death globally. Liver fibrosis is a common pathway/condition involved in all chronic liver …

Nicotinic acid attenuates experimental non-alcoholic steatohepatitis by inhibiting the NLRP3 inflammasome/pyroptosis pathway

I Cardoso-Lezama, MÁ Fuentes-Figueroa… - Biochemical …, 2023 - Elsevier
Non-alcoholic steatohepatitis (NASH) is a global public health concern that may progress
into fibrosis, cirrhosis, and liver cancer, with limited curative treatment options. While the …

The specific NLRP3 antagonist IFM-514 decreases fibrosis and inflammation in experimental murine non-alcoholic steatohepatitis

S Torres, MJ Brol, F Magdaleno… - Frontiers in Molecular …, 2021 - frontiersin.org
Background and Aims: Activation of the inflammasome NLRP3 (NOD-, LRR-and pyrin
domain containing 3) contributes to the development of non-alcoholic fatty liver disease …

Glycyrrhizin alleviates nonalcoholic steatohepatitis via modulating bile acids and meta-inflammation

T Yan, H Wang, L Cao, Q Wang, S Takahashi… - Drug Metabolism and …, 2018 - ASPET
Nonalcoholic steatohepatitis (NASH) is the progressive stage of nonalcoholic fatty liver
disease that may ultimately lead to cirrhosis and liver cancer, and there are few therapeutic …

CBD alleviates liver injuries in alcoholics with high-fat high-cholesterol diet through regulating NLRP3 inflammasome–pyroptosis pathway

X Jiang, Y Gu, Y Huang, Y Zhou, N Pang… - Frontiers in …, 2021 - frontiersin.org
Alcohol abuse and high-fat diet–induced liver diseases have been the most prevalent
chronic liver diseases and the leading reasons for liver transplantation around the world …