NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage …
X Wu, S Fu, Y Liu, H Luo, F Li, Y Wang, M Gao… - Journal of …, 2019 - Springer
Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital
mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently …
mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently …
Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice
S Chen, L Zhao, P Sherchan, Y Ding, J Yu… - Journal of …, 2018 - Springer
Background Neuroinflammation plays an important role in the pathogenesis of intracerebral
hemorrhage (ICH)-induced secondary brain injury. Activation of melanocortin receptor 4 …
hemorrhage (ICH)-induced secondary brain injury. Activation of melanocortin receptor 4 …
Activation of the melanocortin‐1 receptor by NDP‐MSH attenuates oxidative stress and neuronal apoptosis through PI3K/Akt/Nrf2 pathway after intracerebral …
S Fu, X Luo, X Wu, T Zhang, L Gu… - Oxidative medicine …, 2020 - Wiley Online Library
Oxidative stress and neuronal apoptosis play crucial roles in secondary brain injury (SBI)
after intracerebral hemorrhage (ICH). Recently, Nle4‐D‐Phe7‐α‐melanocyte‐stimulating …
after intracerebral hemorrhage (ICH). Recently, Nle4‐D‐Phe7‐α‐melanocyte‐stimulating …
[HTML][HTML] Activation of melanocortin 1 receptor attenuates early brain injury in a rat model of subarachnoid hemorrhage viathe suppression of neuroinflammation …
W Xu, J Mo, U Ocak, ZD Travis, B Enkhjargal, T Zhang… - …, 2020 - Elsevier
Neuroinflammation plays a vital role in early brain injury (EBI) following subarachnoid
hemorrhage (SAH). The hypothesis of this study was that activation of melanocortin 1 …
hemorrhage (SAH). The hypothesis of this study was that activation of melanocortin 1 …
Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats
S Yu, DM Doycheva, M Gamdzyk, Y Yang… - Journal of …, 2021 - Springer
Background Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis
of hypoxic-ischemic (HI)-induced brain injury. Activation of melanocortin-1 receptor (MC1R) …
of hypoxic-ischemic (HI)-induced brain injury. Activation of melanocortin-1 receptor (MC1R) …
Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in …
Z Xie, L Huang, B Enkhjargal, C Reis, W Wan… - Brain, behavior, and …, 2018 - Elsevier
Neuroinflammation is an essential mechanism involved in the pathogenesis of
subarachnoid hemorrhage (SAH)-induced brain injury. Recently, Netrin-1 (NTN-1) is well …
subarachnoid hemorrhage (SAH)-induced brain injury. Recently, Netrin-1 (NTN-1) is well …
Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease
N Mykicki, AM Herrmann, N Schwab… - Science translational …, 2016 - science.org
In inflammation-associated progressive neuroinflammatory disorders, such as multiple
sclerosis (MS), inflammatory infiltrates containing T helper 1 (TH1) and TH17 cells cause …
sclerosis (MS), inflammatory infiltrates containing T helper 1 (TH1) and TH17 cells cause …
[HTML][HTML] CCR1 activation promotes neuroinflammation through CCR1/TPR1/ERK1/2 signaling pathway after intracerebral hemorrhage in mice
J Yan, G Zuo, P Sherchan, L Huang, U Ocak, W Xu… - …, 2020 - Elsevier
The activation of CC chemokine receptor type 1 (CCR1) has been shown to be pro-
inflammatory in several animal models of neurological diseases. The objective of this study …
inflammatory in several animal models of neurological diseases. The objective of this study …
MCC950 attenuated early brain injury by suppressing NLRP3 inflammasome after experimental SAH in rats
Nucleotide oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome is
a multiprotein complex, which results in the inflammatory response in early brain injury (EBI) …
a multiprotein complex, which results in the inflammatory response in early brain injury (EBI) …
MicroRNA-152 attenuates neuroinflammation in intracerebral hemorrhage by inhibiting thioredoxin interacting protein (TXNIP)-mediated NLRP3 inflammasome …
L Hu, H Zhang, B Wang, Q Ao, Z He - International Immunopharmacology, 2020 - Elsevier
Neuroinflammation significantly contributes to brain injury and neurological deterioration
following intracerebral hemorrhage (ICH). MicroRNA-152 (miR-152) was reported to be …
following intracerebral hemorrhage (ICH). MicroRNA-152 (miR-152) was reported to be …
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