[HTML][HTML] Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS-and/or NF-κB-mediated NLRP3 inflammasome …

J Zeng, Y Chen, R Ding, L Feng, Z Fu, S Yang… - Journal of …, 2017 - Springer
Background Intracerebral hemorrhage (ICH) induces potently oxidative stress responses
and inflammatory processes. Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure …

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP 3 inflammasome and apoptosis signaling

Y Dong, C Fan, W Hu, S Jiang, Z Ma… - Journal of pineal …, 2016 - Wiley Online Library
Subarachnoid hemorrhage (SAH) is a devastating condition with high morbidity and
mortality rates due to the lack of effective therapy. Nucleotide‐binding oligomerization …

[HTML][HTML] Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

CC Wei, YY Kong, GQ Li, YF Guan, P Wang… - Scientific reports, 2017 - nature.com
Replenishment of NAD+ has been shown to protect against brain disorders such as
amyotrophic lateral sclerosis and ischemic stroke. However, whether this intervention has …

[HTML][HTML] Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice

N Lai, D Wu, T Liang, P Pan, G Yuan, X Li, H Li… - Journal of …, 2020 - Springer
Background Inflammation is a potential crucial factor in the pathogenesis of subarachnoid
hemorrhage (SAH). Circulating microRNAs (miRNAs) are involved in the regulation of …

[HTML][HTML] MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia

R Infantino, C Schiano, L Luongo, S Paino… - Neurobiology of …, 2022 - Elsevier
Central post-stroke pain (CPSP) and associated depression remain poorly understood and
pharmacological treatments are unsatisfactory. Recently, microglia activation was suggested …

TREM (triggering receptor expressed on myeloid cells)-1 inhibition attenuates neuroinflammation via PKC (protein kinase C) δ/CARD9 (caspase recruitment domain …

Q Lu, R Liu, P Sherchan, R Ren, W He, Y Fang… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Intracerebral hemorrhage (ICH) is a devastating subtype of stroke
with high mortality and disability. Inflammatory response promotes secondary brain injury …

lncRNA Mtss1 promotes inflammatory responses and secondary brain injury after intracerebral hemorrhage by targeting miR-709 in mice

JX Chen, YP Wang, X Zhang, GX Li, K Zheng… - Brain research …, 2020 - Elsevier
Secondary brain injuries following intracerebral hemorrhage (ICH) are mediated by
inflammatory pathway activation. The present study aimed to characterize long noncoding …

Retracted: Vagus Nerve Mediates the Protective Effects of Melanocortins against Cerebral and Systemic Damage after Ischemic Stroke

A Ottani, D Giuliani, C Mioni… - Journal of Cerebral …, 2009 - journals.sagepub.com
A vagus nerve-mediated, efferent cholinergic protective pathway activated by melanocortins
is operative in circulatory shock and myocardial ischemia. Moreover, melanocortins have …

[HTML][HTML] Necrosulfonamide Alleviates Acute Brain Injury of Intracerebral Hemorrhage via Inhibiting Inflammation and Necroptosis

X Zhang, Y Zhang, F Wang, Y Liu, VW Yong… - Frontiers in molecular …, 2022 - frontiersin.org
Objective Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, without
effective treatment. Necrosulfonamide (NSA), a specific inhibitor for mixed lineage kinase …

[HTML][HTML] miR-124-3p inhibits microglial secondary inflammation after basal ganglia hemorrhage by targeting TRAF6 and repressing the activation of NLRP3 …

Y Fang, X Hong - Frontiers in Neurology, 2021 - frontiersin.org
Objectives: Intracerebral hemorrhage (ICH) represents a serious central nervous system
emergency with high morbidity and mortality, and the basal ganglia is the most commonly …