Intracerebral hemorrhage (ICH) has a high mortality and disability rate. Fewer studies focus
on white matter injury (WMI) after ICH, especially the corticospinal tract (CST) injury located …

Background It is generally recognized that the inflammatory reaction in glia is one of the
important pathological factors in brain ischemic injury. Our previous study has revealed that …

MiR-126, a microRNA implicated in blood vessel integrity, angiogenesis and vascular
inflammation, is markedly decreased in the sera of patients with intracerebral hemorrhage …

Background and Purpose—The NLRP3 (nucleotide binding and oligomerization domain-
like receptor family pyrin domain-containing 3) inflammasome is a crucial component of the …

Subarachnoid hemorrhage (SAH) is a devastating subtype of stroke. Microglial macrophage-
inducible C-type lectin (Mincle) receptor launches microglial innate immunity after SAH, and …

Background Celastrol (cel) was one of the earliest isolated and identified chemical
constituents of Tripterygium wilfordii Hook. f. Based on a cel probe (cel-p) that maintained …

Recent studies have identified neuroinflammation as a significant contributor to the
pathological process of traumatic brain injury (TBI) and as a potentially effective target for …

Abstract Background Stroke affects 3–4% of adults and kills numerous people each year.
Recovering blood flow with minimal reperfusion-induced injury is crucial. However, the …

Background Microglial polarization is a dynamic response to acute brain hypoxia induced by
stroke and traumatic brain injury (TBI). However, studies on the polarization of microglia in …

Background Idebenone is a well-appreciated mitochondrial protectant while the
mechanisms underlying the neuroprotection in cerebral ischemia and reperfusion (I/R) …