Objectives To determine the efficacy and safety of different opioids used in doses
proportional to the basal opioid regimen for the management of breakthrough pain (BP) …

The aim of this prospective cohort study was to confirm the safety of intravenous morphine
(IV-M) used in doses proportional to the basal opioid regimen for the management of …

Breakthrough pain is a common and distinct component of cancer pain that is usually
managed with normal release opioids (also known as rescue medication) either before or …

Background: Breakthrough pain (BTP) has not formerly been discussed as such in chronic
non‐malignant pain patients referred to pain centres and clinics. The purpose of the study …

The aim of this study was to present how opioids are used in an acute pain relief and
palliative care unit (APRPCU), where many patients with difficult pain conditions are …

Results: The total number of reported breakthrough pain in all 433 patients for 10 days of
treatment was 3 369 (0.78 BTcP/per patient/day), where at Group 1 patients showed …

Opioid dosing strategies for acute pain differ from strategies for chronic pain management.
The basic principles of effective, safe dosing are rapid titration to the onset of analgesia …

Background There is limited evidence about the response of breakthrough pain (BTP) to the
most commonly used oral immediate‐release (IR) opioids. Our aim was to determine …

The usual management of cancer related breakthrough pain is with supplemental doses of
analgesics (commonly opioids) at a dose proportional to the total around-the-clock opioid …

Russell K. Portenoy, MD: I have been involved in doing a lot of the studies with the new
rapid-onset fentanyl formulations, including the very first one that was on the market, oral …