Affective disorders including depression and anxiety are among the most prevalent
behavioral abnormalities in patients with Alzheimer's disease (AD), which affect the quality …

Compromised cellular energy metabolism, cerebral hypoperfusion, and neuronal calcium
dysregulation are involved in the pathological process of Alzheimer's disease (AD). ATP …

In addition to coupling cell metabolism and excitability, ATP-sensitive potassium channels (K
ATP) are involved in neural function and plasticity. Moreover, alterations in K ATP activity …

A high co-morbidity between Alzheimer's disease (AD) and depression suggests there might
be similar mechanisms underlying the course of these diseases. Previous studies have …

Stress-induced disturbance of the hypothalamic-pituitary-adrenal (HPA) axis is strongly
implicated in incidence of mood disorders. A heightened neuroinflammatory response and …

In spite of characterizing the role of protein kinase A (PKA) in activating biochemical
mechanisms, few studies have investigated the effects of PKA inhibitors on memory …

The dysfunction of the hypothalamus–pituitary–adrenal (HPA) axis is often seen in
Alzheimer's disease (AD) patients with cognitive deficits. Selective inhibition of …

Depression is a serious mental disorder in the world, but the underlying mechanisms remain
unclear and the effective cures are scarce. Iptakalim (Ipt), an ATP-sensitive potassium (K …

Synaptic plasticity damages play a crucial role in the onset and development of depression,
especially in the hippocampus, which is more susceptible to stress and the most frequently …

Extensive clinical and experimental studies established that depression and mood disorders
are highly prevalent neuropsychiatric conditions in Alzheimer's disease (AD). However, its …