A major bottleneck to development of new oral medicines is the poor solubility of many drug
candidates. The need to develop bio-enabling formulations for poorly soluble drug …

Traditionally most pharmaceutical excipients used for peroral dosage forms have been
considered to be inert, although they have been known to play an important role in …

Food-drug interactions frequently hamper oral drug development due to various
physicochemical, physiological and formulation-dependent mechanisms. This has …

One of the most frequent causes for discarding new drug molecules in the first phases of
early drug discovery is their poor bioavailability. The pharmaceutical R&D researcher must …

Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall
elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a …

Abstract Implementation of Quality by Design approaches in pharmaceutical industry
requires a sound understanding of the parameters triggering final product variability …

48 Pharmaceutical Technology MARCH 2003 www. pharmtech. com are not entirely devoid
of pharmacological activity. As parenteral drug delivery becomes more complex and …

The availability of in vitro tools that are constructed on the basis of a detailed knowledge of
key aspects of gastrointestinal (GI) physiology and their impact on formulation performance …

This is a reply to the comment on “In Silico Modeling of Gastrointestinal Drug Absorption:
Predictive Performance of Three Physiologically Based Absorption Models” by Turner and …

Due to the strong tendency towards poorly soluble drugs in modern development pipelines,
enabling drug formulations such as amorphous solid dispersions, cyclodextrins, co-crystals …