[HTML][HTML] Modelling and simulation approaches for waiving in vivo pharmacokinetic formulation studies
H Kortejärvi - 2008 - helda.helsinki.fi
The bioavailability and bioequivalency of oral drug depends on gastrointestinal tract
physiology and drug-related physicochemical and pharmacokinetic factors. In general …
physiology and drug-related physicochemical and pharmacokinetic factors. In general …
Pharmaceutical excipients: A regulatory aspect
The purpose of this study is to understand theregulatory aspects of pharmaceutical
excipients and its role in a dosage form. In earlier days, excipients were considered as …
excipients and its role in a dosage form. In earlier days, excipients were considered as …
[PDF][PDF] THE TALE OF PHARMACEUTICAL EXCIPIENT SELECTION: FROM THE LABORATORY TO THE INDUSTRIAL SCALE.
AD Modi, DM Modi - Pharma Science Monitor, 2022 - researchgate.net
Impact factor: 0.3397/ICV: 4.10 ISSN: 0976-7908 1 THE TALE OF PHARMACEUTICAL
EXCIPIENT SELECTION: FROM THE LABORATORY TO Page 1 Impact factor: 0.3397/ICV …
EXCIPIENT SELECTION: FROM THE LABORATORY TO Page 1 Impact factor: 0.3397/ICV …
Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions
Oral administration of drug products is the preferred administration route. In recent decades
there has been an increase in drug candidates with low solubility and/or low permeability …
there has been an increase in drug candidates with low solubility and/or low permeability …
A Review of:“Handbook of Pharmaceutical Excipients, ” RC Rowe, PJ Sheskey, and SC Owen, editors, Pharmaceutical Press, 2005, Hardback, 928, 0853696187
LA Felton - 2006 - Taylor & Francis
The formulation, development, and manufacturing of drug-delivery systems relies heavily on
the use of excipients to aid in processing, stability, and bioavailability. A detailed knowledge …
the use of excipients to aid in processing, stability, and bioavailability. A detailed knowledge …
Physiologically based absorption modeling to impact biopharmaceutics and formulation strategies in drug development—industry case studies
F Kesisoglou, J Chung, J van Asperen… - Journal of …, 2016 - Elsevier
In recent years, there has been a significant increase in use of physiologically based
pharmacokinetic models in drug development and regulatory applications. Although most of …
pharmacokinetic models in drug development and regulatory applications. Although most of …
[HTML][HTML] Computational prediction of formulation strategies for beyond-rule-of-5 compounds
The physicochemical properties of some contemporary drug candidates are moving towards
higher molecular weight, and coincidentally also higher lipophilicity in the quest for …
higher molecular weight, and coincidentally also higher lipophilicity in the quest for …
Striving towards the perfect in vitro oral drug absorption model
JP Gleeson, F McCartney - Trends in pharmacological sciences, 2019 - cell.com
Oral drug delivery systems have multiple goals, assessing and enabling intestinal
absorption at efficacious doses being one of them. Here we highlight the in vitro advances in …
absorption at efficacious doses being one of them. Here we highlight the in vitro advances in …