The aim of this study was to test the hypothesis that persistent myocardial apoptosis
contributes to progression of heart failure in a canine model of pacing-induced …

Objective: Rapid ventricular pacing in dogs results in a low output cardiomyopathic state
similar to idiopathic dilated cardiomyopathy in man. Cell death by apoptosis may play an …

Background—Rapid ventricular pacing in dogs is characterized by a dilated myopathy in
which myocyte cell death by apoptosis may play a significant role in the impairment of …

BACKGROUND: Specific myocardial mitochondrial enzymatic dysfunction and apoptotic
remodeling occur in pacing-induced heart failure. We sought to define their regional …

Cell death has been questioned as a mechanism of ventricular failure. In this report, we
tested the hypothesis that apoptotic death of myocytes, endothelial cells, and fibroblasts is …

Background Observations in humans have raised the possibility that idiopathic dilated
cardiomyopathy is characterized by myocyte cell loss and cell proliferation, which contribute …

BACKGROUND: Cardiomyocyte apoptosis is implicated in the pathogenesis of heart failure
and mitochondria play an important role in this mode of cell death. In this study, activity of the …

The role of myocardial apoptosis during the development of heart failure (HF), in the
absence of coronary artery stenosis, is still debated. The aim of the study was to evaluate …

Background—Left ventricular hypertrophy (LVH) represents both an adaptive response to
increased cardiac work load and a precursor state of heart failure. Recent evidence linked …

This study examined sex differences in the regulation of pro-and anti-apoptotic proteins in
cardiac hypertrophy and heart failure due to volume overload induced by arteriovenous (AV) …