To enter the nucleus, a protein must transit through one of the largest and most complex
gateways in the eukary-otic cell, the nuclear pore. Consisting of perhaps 1000 proteins (60 …

The past year has seen the publication of a number of papers describing the identification of
cytosolic factors involved in import of proteins to the nucleus. Although, at first glance, this …

The past two years have seen a significant increase in our understanding of nuclear protein
import. Five cytosolic import factors have been identified, two of which have been shown to …

Transport of proteins, RNAs and ribonucleoprotein particles into and out of the nucleus is
essential for many cellular functions to proceed. Recent progress in this area of research …

Nuclear transport may be the cell's most complex macromolecular membrane trafficking
process. Proteins, RNAs, and fully assembled rlbonucleoprotein particles are transported …

The term nuclear transport, refers to the movement of a large variety of macromolecules both
into and out of the nucleus. Transport must be extremely selective, yet also very efficient. A …

After synthesis in the cytoplasm, nuclear proteins traverse the nuclear envelope as a result
of the specific recognition of nuclear localization signals by import. Various approaches …

Macromolecules enter or leave the nucleus by using nuclear localization signals (NLS), or
nuclear export signals (NES), respectively. Different types of NLS and NES are recognized …

Recent progress indicates that there are multiple pathways of nucleocytoplasmic transport
which involve specific targeting sequences, such as nuclear localization sequences (NLSs) …

The nuclear import of proteins into the cell nucleus involves the recognition of a nuclear
localization signal sequence, borne by the protein to be transported, by complex molecules …