In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance‐associated mutations of Plasmodium …

ID Ferreira, D Lopes, A Martinelli… - Tropical Medicine & …, 2007 - Wiley Online Library
Objective To evaluate the basal in vitro responses of Plasmodium falciparum isolates
collected in The Democratic Republic of São Tomé and Príncipe to artemether (ATH) …

Plasmodium falciparum from Pará state (Brazil) shows satisfactory in vitro response to artemisinin derivatives and absence of the S769N mutation in the SERCA‐type …

ID Ferreira, A Martinelli, LA Rodrigues… - Tropical Medicine & …, 2008 - Wiley Online Library
Objective To evaluate the in vitro efficacy of artesunate (ATN) and artemether (ATH) against
Plasmodium falciparum isolates from the Brazilian Amazon state of Pará and to search for …

[HTML][HTML] Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based …

BE Gama, NKA de Oliveira, JM de Souza, F Santos… - Malaria Journal, 2010 - Springer
Background This study was performed to better understand the genetic diversity of known
polymorphisms in pfatpase6 and pfmdr1 genes before the introduction of ACT in Brazil, in …

Exploring the Contribution of Candidate Genes to Artemisinin Resistance in Plasmodium falciparum

M Imwong, AM Dondorp, F Nosten, P Yi… - Antimicrobial agents …, 2010 - Am Soc Microbiol
The reduced in vivo sensitivity of Plasmodium falciparum has recently been confirmed in
western Cambodia. Identifying molecular markers for artemisinin resistance is essential for …

Molecular profile of malaria drug resistance markers of Plasmodium falciparum in Suriname

SM Chenet, SA Okoth, J Kelley, N Lucchi… - Antimicrobial agents …, 2017 - Am Soc Microbiol
In Suriname, an artesunate monotherapy therapeutic efficacy trial was recently conducted to
evaluate partial artemisinin resistance emerging in Plasmodium falciparum. We genotyped …

[HTML][HTML] Profile of molecular mutations in pfdhfr, pfdhps, pfmdr1, and pfcrt genes of Plasmodium falciparum related to resistance to different anti-malarial drugs in …

P Berzosa, A Esteban-Cantos, L García, V González… - Malaria Journal, 2017 - Springer
Background The emergence of drug resistance in Plasmodium falciparum has been a major
contributor to the global burden of malaria. Drug resistance complicates treatment, and it is …

[PDF][PDF] Analysis of pfcrt, pfmdr1, dhfr and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment …

T Ngo, M Duraisingh, M Reed, D Hipgrave… - American Journal of …, 2003 - academia.edu
We have analyzed artemisinin sensitivity in Plasmodium falciparum isolates obtained from
patients in South Vietnam and show that artemisinin sensitivity does not differ before and …

[HTML][HTML] Molecular surveillance of drug-resistance associated mutations of Plasmodium falciparum in south-west Tanzania

M Schönfeld, I Barreto Miranda, M Schunk, I Maduhu… - Malaria Journal, 2007 - Springer
Abstract Background In Tanzania, drug-resistant malaria parasites are an increasing public
health concern. Because of widespread chloroquine (CQ) resistance Tanzania changed its …

[HTML][HTML] Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal, in 2010: an ex vivo and drug resistance molecular markers study

B Fall, A Pascual, FD Sarr, N Wurtz, V Richard, E Baret… - Malaria Journal, 2013 - Springer
Abstract Background In 2006, the Senegalese National Malaria Control Programme
recommended artemisinin-based combination therapy (ACT) as the first-line treatment for …

The role of pfmdr1 in Plasmodium falciparum tolerance to artemether‐lumefantrine in Africa

C Sisowath, PE Ferreira, LY Bustamante… - Tropical Medicine & …, 2007 - Wiley Online Library
Summary Objective Artemether‐lumefantrine (AL), presently the most favoured combination
therapy against uncomplicated Plasmodium falciparum malaria in Africa, has recently shown …