Background: Irritability is prevalent and impairing in pediatric bipolar disorder (BD) but has
been minimally studied using neuroimaging techniques. We used …

Questions persist regarding the presentation of bipolar disorder (BD) in youth and the
nosological significance of irritability. Of particular interest is whether severe mood …

Objective: Researchers disagree as to whether irritability is a diagnostic indicator for
pediatric mania in bipolar disorder. The authors compared the behavioral and …

OBJECTIVE: To use functional neuroimaging to probe the affective circuitry dysfunctions
underlying disturbances in emotion processing and emotional reactivity in pediatric bipolar …

Objectives Frustration is associated with impaired attention, heightened arousal, and greater
unhappiness in youths with bipolar disorder (BD) vs healthy volunteers (HV). Little is known …

The pathophysiology of pediatric bipolar disorder (PBD) impacts both affective and cognitive
brain systems. Understanding disturbances in the neural circuits subserving these abilities is …

This fMRI study investigates the neural bases of cognitive control of emotion processing in
pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD) …

OBJECTIVE: Outcome and family history data differentiate children with severe mood
dysregulation (SMD), a syndrome characterized by chronic irritability, from children with …

Objectives: Previous studies have indicated abnormalities in response flexibility in pediatric
bipolar disorder (BD). Dysfunction in response flexibility may contribute to the pattern of …

Objective Irritability is common in children and adolescents and is the cardinal symptom of
disruptive mood dysregulation disorder, a new DSM-5 disorder, yet its neural correlates …