Statins are potent inhibitors of HMG-CoA reductase, the key rate-limiting enzyme in
cholesterol biosynthesis, and are some of the best selling drugs globally. We have explored …

Cholesterol is a key component of cell membranes with a proven modulatory role on the
function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal …

Mammalian cells control their membrane composition by regulating the vesicular transport of
membrane-bound sterol regulatory element binding proteins (SREBPs) from endoplasmic …

Cholesterol-rich membrane domains function in various membrane events as diverse as
signal transduction and membrane traffic. We studied the interaction of a fluorescein ester of …

Cholesterol is a multifunctional lipid in eukaryotic cells. It regulates the physical state of the
phospholipid bilayer, is crucially involved in the formation of membrane microdomains …

C2 domains are membrane-binding modules that share a common overall fold: a single
compact Greek-key motif organized as an eight-stranded anti-parallel β-sandwich consisting …

The spatial organization of transmembrane receptors is a critical step in signal transduction
and receptor trafficking in cells. Transmembrane receptors engage in lateral homotypic and …

The well-known family of low-density lipoprotein receptors represents a collection of ancient
membrane receptors that have been remarkably conserved throughout evolution. These …

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We
find that cholesterol is not just necessary but also sufficient to activate signaling by the …

J. Neurochem.(2011) 116, 684–689. Abstract Lipids are essential for the structural and
functional integrity of membranes. Membrane lipids are not randomly distributed but are …