A mathematical model of fatigue in skeletal muscle force contraction

PR Shorten, P O'Callaghan, JB Davidson… - Journal of muscle …, 2007 - Springer
The ability for muscle to repeatedly generate force is limited by fatigue. The cellular
mechanisms behind muscle fatigue are complex and potentially include breakdown at many …

Peripheral fatigue: new mechanistic insights from recent technologies

E Cè, S Longo, E Limonta, G Coratella… - European Journal of …, 2020 - Springer
Peripheral fatigue results from multiple electrochemical and mechanical events in the cell
body and the muscle–tendon complex. Combined force and surface electromyographic …

Mechanisms of in vivo muscle fatigue in humans: investigating age‐related fatigue resistance with a computational model

DM Callahan, BR Umberger… - The Journal of physiology, 2016 - Wiley Online Library
Key points Muscle fatigue can be defined as the transient decrease in maximal force that
occurs in response to muscle use. Fatigue develops because of a complex set of changes …

Cellular mechanisms of fatigue in skeletal muscle

H Westerblad, JA Lee… - American Journal of …, 1991 - journals.physiology.org
Prolonged activation of skeletal muscle leads to a decline of force production known as
fatigue. In this review we outline the ionic and metabolic changes that occur in muscle …

Skeletal muscle fatigue

JA Kent‐Braun, RH Fitts… - Comprehensive Physiology, 2011 - Wiley Online Library
Skeletal muscle fatigue is defined as the fall of force or power in response to contractile
activity. Both the mechanisms of fatigue and the modes used to elicit it vary tremendously …

Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres

N Place, T Yamada, JD Bruton… - European journal of …, 2010 - Springer
Prolonged dynamic exercise and sustained isometric contractions induce muscle fatigue, as
manifested by decreased performance and a reduction in the maximum voluntary …

Cellular mechanisms of muscle fatigue

RH Fitts - Physiological reviews, 1994 - journals.physiology.org
Fatigue, defined as the failure to maintain the required or expected power output, is a
complex problem, since multiple factors are clearly involved, with the relative importance of …

Skeletal muscle fatigue: cellular mechanisms

DG Allen, GD Lamb, H Westerblad - Physiological reviews, 2008 - journals.physiology.org
Repeated, intense use of muscles leads to a decline in performance known as muscle
fatigue. Many muscle properties change during fatigue including the action potential …

A motor unit-based model of muscle fatigue

JR Potvin, AJ Fuglevand - PLoS computational biology, 2017 - journals.plos.org
Muscle fatigue is a temporary decline in the force and power capacity of skeletal muscle
resulting from muscle activity. Because control of muscle is realized at the level of the motor …

No Muscle Is an Island: Integrative Perspectives on Muscle Fatigue.

JA Kent, N Ørtenblad, MC Hogan… - Medicine and science …, 2016 - europepmc.org
Muscle fatigue has been studied with a variety approaches, tools and technologies. The foci
of these studies have ranged tremendously, from molecules to the entire organism. Single …