CD20 antibody depletion of B lymphocytes effectively ameliorates multiple T cell-mediated
autoimmune diseases through mechanisms that remain unclear. To address this, a mouse …

The basic understanding of inflammatory dermatoses and autoimmune-mediated skin
disorders has greatly advanced and broadened our understanding of underlying immune …

B lymphocytes contribute to the pathogenesis of autoimmune disorders since B‐cell
depletion treatment improves such diseases. However, B cells seem ambivalent. Murine …

Over the past decade, a growing recognition of the importance of neutralizing antibodies in
host defense combined with the success of B‐cell depletion therapies in treating auto …

B cell hyperactivity and breach of tolerance constitute hallmarks of systemic lupus
erythematosus (SLE). The heterogeneity of disease manifestations and relatively rare …

Highlights•B cells are emerging as effective therapeutic targets in many autoimmune
diseases.•While B cell depleting therapies are efficacious, they are not without safety …

B-lymphocytes have traditionally been thought to contribute to immunity and autoimmune
disease through terminal differentiation into plasma cells that secrete antibody. However …

Regulatory functions for B lymphocytes have been reported in murine models of
autoimmune diseases in which B-cell deficient mice were shown to exhibit exacerbated …

B cells play a central role in the pathogenesis of multiple autoimmune diseases and the
recognition of the importance of B cells in these disorders has grown dramatically in …

Objective B‐1 cells have long been suggested to play an important role in lupus. However,
reports to date have been controversial regarding their pathogenic or protective roles in …