Neuronal activity causes local changes in cerebral blood flow, blood volume, and blood
oxygenation. Magnetic resonance imaging (MRI) techniques sensitive to changes in …

Changes in cerebral blood oxygenation due to functional activation of the primary
sensorimotor cortex during a unilateral finger opposition task were simultaneously mapped …

Recent studies from our group and others using quantitative fMRI methods have found that
variations of the coupling ratio of blood flow (CBF) and oxygen metabolism (CMRO2) …

The purpose of this study was to establish the relationship between regional CBF and CBV
at normal, resting cerebral metabolic rates. Eleven healthy volunteers were investigated with …

Using gradient‐echo echo‐planar MRI, a local signal increase of 4.3±0.3% is observed in
the human brain during task activation, suggesting a local decrease in blood …

The most widely‐used functional magnetic resonance imaging (fMRI) technique is based on
the blood oxygenation level dependent (BOLD) effect, which requires at least partial …

Fast, low-angle shoot functional magnetic resonance imaging (fMRI), based on the blood
oxygenation level-dependent (BOLD) effect, was combined with optical recording of intrinsic …

The blood oxygenation level-dependent (BOLD) contrast mechanism can be modeled as a
complex interplay between CBF, cerebral blood volume (CBV), and CMRO2. Positive BOLD …

Cerebral hemodynamic responses to brief periods of neural activity are delayed and
dispersed in time. The specific shape of these responses is of some importance to the …

Over the last 30 years the development of new and exciting techniques has enabled us to
observe the localization of function in the human brain and to discover how the working …