Melanoma cells can enter the process of senescence, but whether they express a secretory
phenotype, as reported for other cells, is undetermined. This is of paramount importance …

Here, we showed that the secretome of senescent melanoma cells drives basal melanoma
cells towards a mesenchymal phenotype, with characteristic of stems illustrated by …

Cellular senescence has emerged as a potent tumor suppressor mechanism in numerous
human neoplasias. Senescent cells secrete a distinct set of factors, collectively termed the …

Cellular senescence acts as a potent barrier to tumorigenesis and contributes to the anti-
tumor activity of certain chemotherapeutic agents. Senescent cells undergo a stable cell …

Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

Cellular senescence is a permanent growth arrest that is broadly recognized to act as a
barrier against tumorigenesis. Senescence is predominant in premalignant tumors, and …

Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated …

Cancer is a devastating disease that increases exponentially with age. Cancer arises from
cells that proliferate in an unregulated manner, an attribute that is countered by cellular …

Cellular senescence in cancer development is known to have tumor‐suppressive and tumor‐
promoting roles. Recent studies have revealed numerous molecular mechanisms of …

Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …