Microfluidic tumors‐on‐chips models have revolutionized anticancer therapeutic research
by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) …

Three-dimensional cancer-on-a-chip tissue models aim to replicate the key hallmarks of the
tumour microenvironment and allow for the study of dynamic interactions that occur during …

Simple Summary Microfluidic-based cancer-on-a-chip models are powerful tools to study the
tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In …

Abstract The concept of Cancer Stem Cells (CSCs) and the CSC Niche/Tumor
Microenvironment (TME) as the central driving force behind tumor progression and …

Microfluidic chips are valuable tools for studying intricate cellular and cell–microenvironment
interactions. Traditional in vitro cancer models lack accuracy in mimicking the complexities …

Abstract Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for
3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC …

Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …

Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed
through metastasis, a complex and poorly understood process. Cues from the tumor …

Currently, despite the vast amounts of time and money invested in cancer treatment, cancer
remains one of the primary threats to human life. The primary factor contributing to the low …

Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal
interactions between cancer stem cells and niche contribute to the maintenance and …