HIV-associated neurotoxicity and cognitive decline: Therapeutic implications

DR Wallace - Pharmacology & Therapeutics, 2022 - Elsevier
As our understanding of changes to the neurological system has improved, it has become
clear that patients who have contracted human immunodeficiency virus type 1 (HIV-1) can …

HIV neurotoxicity: potential therapeutic interventions

DR Wallace - BioMed Research International, 2006 - Wiley Online Library
Individuals suffering from human immunodeficiency virus type 1 (HIV‐1) infection suffer from
a wide range of neurological deficits. The most pronounced are the motor and cognitive …

Could antiretroviral neurotoxicity play a role in the pathogenesis of cognitive impairment in treated HIV disease?

J Underwood, KR Robertson, A Winston - Aids, 2015 - journals.lww.com
Whilst effective antiretroviral therapy is protective against the more severe forms of HIV-
associated brain disease, there remains a large burden of clinically symptomatic cognitive …

HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities

KA Lindl, DR Marks, DL Kolson… - Journal of neuroimmune …, 2010 - Springer
Human immunodeficiency virus type 1 (HIV) infection presently affects more that 40 million
people worldwide, and is associated with central nervous system (CNS) disruption in at least …

Developing neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction

JA Rumbaugh, J Steiner, N Sacktor, A Nath - Future HIV therapy, 2008 - Taylor & Francis
Important advances have been made in recent years in identifying the molecular
mechanisms of HIV neuropathogenesis. Defining the pathways leading to HIV dementia has …

HIV-associated neurocognitive disorders and antiretroviral therapy: current concepts and controversies

MR Etherton, JL Lyons, KL Ard - Current infectious disease reports, 2015 - Springer
Antiretroviral drugs may help prevent neurological decline in individuals with HIV infection
by suppressing viral replication and associated chronic immune activation in the central …

Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management

RJ Ellis, MJ Marquine, M Kaul, JA Fields… - Nature Reviews …, 2023 - nature.com
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Treatment of HIV in the CNS: effects of antiretroviral therapy and the promise of non-antiretroviral therapeutics

MJ Peluso, S Spudich - Current HIV/AIDS Reports, 2014 - Springer
The growing recognition of the burden of neurologic disease associated with HIV infection in
the last decade has led to renewed efforts to characterize the pathophysiology of the virus …

CNS neurotoxicity of antiretrovirals

T Lanman, S Letendre, Q Ma, A Bang… - Journal of Neuroimmune …, 2021 - Springer
The development of novel antiretroviral treatments has led to a significant turning point in the
fight against HIV. Although therapy leads to virologic suppression and prolonged life …

Neurobiology of HIV

B Hult, G Chana, E Masliah, I Everall - International Review of …, 2008 - Taylor & Francis
The importance of HIV cognitive impairment, including HIV associated dementia (HAD) and
minor cognitive/motor disorder, has continued in the era of highly active antiretroviral …