Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

Glial scarring following severe tissue damage and inflammation after spinal cord injury (SCI)
is due to an extreme, uncontrolled form of reactive astrogliosis that typically occurs around …

Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …

Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Spinal cord and brain injuries lead to complex cellular and molecular interactions within the
central nervous system in an attempt to repair the initial tissue damage. Many studies have …

Scar formation represents a reaction of nervous tissue to any form of physical injury.
Research over the past decade has demonstrated that the scar composed of glial cells and …

Astroglial scars surround damaged tissue after trauma, stroke, infection, or autoimmune
inflammation in the CNS. They are essential for wound repair, but also interfere with axonal …

Injury or disease to the CNS results in multifaceted cellular and molecular responses. One
such response, the glial scar, is a structural formation of reactive glia around an area of …

The failure of axonal regeneration after spinal cord injury (SCI) results in permanent loss of
sensorimotor function. The persistent presence of scar tissue, mainly fibrotic scar and …